Sacchi V, Wang BJ, Kubli D, Martinez AS, Jin JK, Alvarez R, Hariharan N, Glembotski C, Uchida T, Malter JS, Yang Y, Gross P, Zhang C, Houser S, Rota M, Sussman MA Peptidyl-Prolyl Isomerase 1 Regulates Ca2+ Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na2+/Ca2+ Exchanger 1 Protein Levels and Function. J Am Heart Assoc 2017 Oct 10 6(10):. Epub 2017 Oct 10

Khalafalla FG, Kayani W, Kassab A, Ilves K, Monsanto MM, Alvarez R, Chavarria M, Norman B, Dembitsky WP, Sussman MA Empowering human cardiac progenitor cells by P2Y14 nucleotide receptor overexpression. J. Physiol. (Lond.) 2017 Dec 01 595(23):7135-7148. Epub 2017 Nov 09

Khalafalla FG, Greene S, Khan H, Ilves K, Monsanto MM, Alvarez R, Chavarria M, Nguyen J, Norman B, Dembitsky WP, Sussman MA P2Y2 Nucleotide Receptor Prompts Human Cardiac Progenitor Cell Activation by Modulating Hippo Signaling. Circ. Res. 2017 Nov 10 121(11):1224-1236. Epub 2017 Sep 18

Sussman MA Cardiac Stem Cells: Working Independently Together. J. Am. Coll. Cardiol. 2017 Aug 08 70(6):742-744.

Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB Accumulation of mitochondrial DNA mutations disrupts cardiac progenitor cell function and reduces survival. J. Biol. Chem. 2017 Jul 07 292(27):11348.

Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser S, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA Cardiomyocyte Regeneration: A Consensus Statement. Circulation 2017 Aug 15 136(7):680-686. Epub 2017 Jul 06

Gude NA, Sussman MA Chasing c-Kit through the heart: Taking a broader view. Pharmacol. Res. 2017 Jun 13 :. Epub 2017 Jun 13

Fernández-Avilés F, Sanz-Ruiz R, Climent AM, Badimon L, Bolli R, Charron D, Fuster V, Janssens S, Kastrup J, Kim HS, Lüscher TF, Martin JF, Menasché P, Simari RD, Stone GW, Terzic A, Willerson JT, Wu JC, , , , , , , , , , Global position paper on cardiovascular regenerative medicine. Eur. Heart J. 2017 Sep 01 38(33):2532-2546.

Monsanto MM, Wang BJ, Sussman MA Synthetic MSC? Nothing Beats the Real Thing. Circ. Res. 2017 May 26 120(11):1694-1695.

Monsanto MM, White KS, Kim T, Wang BJ, Fisher K, Ilves K, Khalafalla FG, Casillas A, Broughton K, Mohsin S, Dembitsky WP, Sussman MA Concurrent Isolation of 3 Distinct Cardiac Stem Cell Populations From a Single Human Heart Biopsy. Circ. Res. 2017 Jul 07 121(2):113-124. Epub 2017 Apr 26

Kubli DA, Sussman MA Eat, breathe, ROS: controlling stem cell fate through metabolism. Expert Rev Cardiovasc Ther 2017 May 15(5):345-356. Epub 2017 Apr 21

Liu N, Wang BJ, Broughton KM, Alvarez R, Siddiqi S, Loaiza R, Nguyen N, Quijada P, Gude N, Sussman MA PIM1-minicircle as a therapeutic treatment for myocardial infarction. PLoS ONE 2017 12(3):e0173963. Epub 2017 Mar 21

Sussman MA A Matter of Opinion. Circ. Res. 2017 Jan 06 120(1):36-38.

Broughton KM, Sussman MA Myocardial Regeneration for Humans - Modifying Biology and Manipulating Evolution. Circ. J. 2017 Jan 25 81(2):142-148. Epub 2016 Dec 27

Kulandavelu S, Karantalis V, Fritsch J, Hatzistergos KE, Loescher VY, McCall F, Wang B, Bagno L, Golpanian S, Wolf A, Grenet J, Williams A, Kupin A, Rosenfeld A, Mohsin S, Sussman MA, Morales A, Balkan W, Hare JM Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine. J. Am. Coll. Cardiol. 2016 Dec 06 68(22):2454-2464.

Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Völkers M S100A4 protects the myocardium against ischemic stress. J. Mol. Cell. Cardiol. 2016 Nov 100:54-63. Epub 2016 Oct 06

Sussman MA Inject Me Once and Inject Me Twice. Then Inject Me Once Again. Circ. Res. 2016 Aug 19 119(5):580-1.

Sin J, Puccini JM, Huang C, Konstandin MH, Gilbert PE, Sussman MA, Gottlieb RA, Feuer R Correction: The Impact of Juvenile Coxsackievirus Infection on Cardiac Progenitor Cells and Postnatal Heart Development. PLoS Pathog. 2016 May 12(5):e1005673. Epub 2016 May 24

Castaldi A, Chesini GP, Taylor AE, Sussman MA, Brown JH, Purcell NH Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. Cell. Signal. 2016 08 28(8):871-9. Epub 2016 Apr 14

Broughton KM, Sussman MA Empowering Adult Stem Cells for Myocardial Regeneration V2.0: Success in Small Steps. Circ. Res. 2016 Mar 04 118(5):867-80.

Samse K, Hariharan N, Sussman MA Personalizing cardiac regenerative therapy: At the heart of Pim1 kinase. Pharmacol. Res. 2016 Jan 103:13-6. Epub 2015 Nov 10

Quijada P, Hariharan N, Cubillo JD, Bala KM, Emathinger JM, Wang BJ, Ormachea L, Bers DM, Sussman MA, Poizat C Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment. J. Biol. Chem. 2015 Oct 16 290(42):25411-26. Epub 2015 Aug 31

Quijada P, Salunga HT, Hariharan N, Cubillo JD, El-Sayed FG, Moshref M, Bala KM, Emathinger JM, De La Torre A, Ormachea L, Alvarez R, Gude NA, Sussman MA Cardiac Stem Cell Hybrids Enhance Myocardial Repair. Circ. Res. 2015 Sep 25 117(8):695-706. Epub 2015 Jul 30

Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival. J. Biol. Chem. 2015 Sep 04 290(36):22061-75. Epub 2015 Jul 16

Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circ. Res. 2015 Aug 28 117(6):536-46. Epub 2015 Jul 02

Monsanto M, Sussman MA Myocardial Infarct Scar: Hunting Down the Responsible Cells, But Then What? J. Am. Coll. Cardiol. 2015 May 19 65(19):2067-9.

Gude N, Joyo E, Toko H, Quijada P, Villanueva M, Hariharan N, Sacchi V, Truffa S, Joyo A, Voelkers M, Alvarez R, Sussman MA Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells. Basic Res. Cardiol. 2015 May 110(3):29. Epub 2015 Apr 19

Hariharan N, Sussman MA Cardiac aging - Getting to the stem of the problem. J. Mol. Cell. Cardiol. 2015 Jun 83:32-6. Epub 2015 Apr 14

Samse K, Emathinger J, Hariharan N, Quijada P, Ilves K, Völkers M, Ormachea L, De La Torre A, Orogo AM, Alvarez R, Din S, Mohsin S, Monsanto M, Fischer KM, Dembitsky WP, Gustafsson ÅB, Sussman MA Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells. J. Biol. Chem. 2015 May 29 290(22):13935-47. Epub 2015 Apr 16

Nguyen N, Sussman MA Rejuvenating the senescent heart. Curr. Opin. Cardiol. 2015 May 30(3):235-9.

Quijada P, Sussman MA Circulating around the tissue: hematopoietic cell-based fusion versus transdifferentiation. Circ. Res. 2015 Feb 13 116(4):563-5.

Hariharan N, Quijada P, Mohsin S, Joyo A, Samse K, Monsanto M, De La Torre A, Avitabile D, Ormachea L, McGregor MJ, Tsai EJ, Sussman MA Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging. J. Am. Coll. Cardiol. 2015 Jan 20 65(2):133-47.

Siddiqi S, Sussman MA The heart: mostly postmitotic or mostly premitotic? Myocyte cell cycle, senescence, and quiescence. Can J Cardiol 2014 Nov 30(11):1270-8. Epub 2014 Aug 23

Sussman MA, Puceat M Response to letter regarding article, "Embryonic stem cell-derived cardiac myocytes are not ready for human trials". Circ. Res. 2014 Oct 24 115(10):e30-1.

Quijada P, Sussman MA Making it stick: chasing the optimal stem cells for cardiac regeneration. Expert Rev Cardiovasc Ther 2014 Nov 12(11):1275-88.

Gaetani R, Feyen DA, Doevendans PA, Gremmels H, Forte E, Fledderus JO, Ramjankhan FZ, Messina E, Sussman MA, Giacomello A, Sluijter JP Different types of cultured human adult cardiac progenitor cells have a high degree of transcriptome similarity. J. Cell. Mol. Med. 2014 Nov 18(11):2147-51. Epub 2014 Oct 14

Panopoulos A, Pacios-Bras C, Choi J, Yenjerla M, Sussman MA, Fotedar R, Margolis RL Failure of cell cleavage induces senescence in tetraploid primary cells. Mol. Biol. Cell 2014 Oct 15 25(20):3105-18. Epub 2014 Aug 20

Sin J, Puccini JM, Huang C, Konstandin MH, Gilbert PE, Sussman MA, Gottlieb RA, Feuer R The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. PLoS Pathog. 2014 Jul 10(7):e1004249. Epub 2014 Jul 31

Hariharan N, Sussman MA Pin1: a molecular orchestrator in the heart. Trends Cardiovasc. Med. 2014 Aug 24(6):256-62. Epub 2014 Jun 04

Anderson ME, Goldhaber J, Houser SR, Puceat M, Sussman MA Embryonic stem cell-derived cardiac myocytes are not ready for human trials. Circ. Res. 2014 Jul 18 115(3):335-8. Epub 2014 Jun 16

Din S, Konstandin MH, Johnson B, Emathinger J, Völkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases. Circ. Res. 2014 Jul 18 115(3):376-87. Epub 2014 Jun 10

Hariharan N, Sussman MA Stressing on the nucleolus in cardiovascular disease. Biochim. Biophys. Acta 2014 Jun 1842(6):798-801. Epub 2013 Oct 24

Völkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity. EMBO Mol Med 2014 01 6(1):57-65.

Toko H, Hariharan N, Konstandin MH, Ormachea L, McGregor M, Gude NA, Sundararaman B, Joyo E, Joyo AY, Collins B, Din S, Mohsin S, Uchida T, Sussman MA Differential regulation of cellular senescence and differentiation by prolyl isomerase Pin1 in cardiac progenitor cells. J. Biol. Chem. 2014 Feb 28 289(9):5348-56. Epub 2013 Dec 27

McGregor M, Hariharan N, Joyo AY, Margolis RL, Sussman MA CENP-A is essential for cardiac progenitor cell proliferation. Cell Cycle 2014 13(5):739-48. Epub 2013 Dec 20

Siddiqi S, Sussman MA Cardiac Hegemony of Senescence. Curr Transl Geriatr Exp Gerontol Rep 2013 Dec 2(4):.

Mohsin S, Wu JC, Sussman MA Predicting the future with stem cells. Circulation 2014 Jan 14 129(2):136-8. Epub 2013 Nov 18

Mohsin S, Khan M, Nguyen J, Alkatib M, Siddiqi S, Hariharan N, Wallach K, Monsanto M, Gude N, Dembitsky W, Sussman MA Rejuvenation of human cardiac progenitor cells with Pim-1 kinase. Circ. Res. 2013 Oct 25 113(10):1169-79. Epub 2013 Sep 17

Völkers M, Konstandin MH, Doroudgar S, Toko H, Quijada P, Din S, Joyo A, Ornelas L, Samse K, Thuerauf DJ, Gude N, Glembotski CC, Sussman MA Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage. Circulation 2013 Nov 05 128(19):2132-44. Epub 2013 Sep 05

Khan M, Mohsin S, Toko H, Alkatib M, Nguyen J, Truffa S, Gude N, Chuprun K, Tilley DG, Koch WJ, Sussman MA Cardiac progenitor cells engineered with βARKct have enhanced β-adrenergic tolerance. Mol. Ther. 2014 Jan 22(1):178-85. Epub 2013 Sep 03

Siddiqi S, Sussman MA Cell and gene therapy for severe heart failure patients: the time and place for Pim-1 kinase. Expert Rev Cardiovasc Ther 2013 Aug 11(8):949-57.

Konstandin MH, Völkers M, Collins B, Quijada P, Quintana M, De La Torre A, Ormachea L, Din S, Gude N, Toko H, Sussman MA Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth. Basic Res. Cardiol. 2013 Sep 108(5):375. Epub 2013 Aug 04

Völkers M, Toko H, Doroudgar S, Din S, Quijada P, Joyo AY, Ornelas L, Joyo E, Thuerauf DJ, Konstandin MH, Gude N, Glembotski CC, Sussman MA Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1. Proc. Natl. Acad. Sci. U.S.A. 2013 Jul 30 110(31):12661-6. Epub 2013 Jul 10

Thomas RL, Roberts DJ, Kubli DA, Lee Y, Quinsay MN, Owens JB, Fischer KM, Sussman MA, Miyamoto S, Gustafsson ÅB Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure. Genes Dev. 2013 Jun 15 27(12):1365-77.

Konstandin MH, Toko H, Gastelum GM, Quijada P, De La Torre A, Quintana M, Collins B, Din S, Avitabile D, Völkers M, Gude N, Fässler R, Sussman MA Fibronectin is essential for reparative cardiac progenitor cell response after myocardial infarction. Circ. Res. 2013 Jul 05 113(2):115-25. Epub 2013 May 07

Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, Joyo AY, Quijada P, Erhardt P, Magnuson NS, Konstandin MH, Sussman MA Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proc. Natl. Acad. Sci. U.S.A. 2013 Apr 09 110(15):5969-74. Epub 2013 Mar 25

Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, Uchida T, Sussman MA Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circ. Res. 2013 Apr 26 112(9):1244-52. Epub 2013 Mar 13

Khan M, Mohsin S, Avitabile D, Siddiqi S, Nguyen J, Wallach K, Quijada P, McGregor M, Gude N, Alvarez R, Tilley DG, Koch WJ, Sussman MA β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation. Circ. Res. 2013 Feb 01 112(3):476-86. Epub 2012 Dec 14

Williams AR, Hatzistergos KE, Addicott B, McCall F, Carvalho D, Suncion V, Morales AR, Da Silva J, Sussman MA, Heldman AW, Hare JM Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. Circulation 2013 Jan 15 127(2):213-23. Epub 2012 Dec 05

Tufan H, Zhang XH, Haghshenas N, Sussman MA, Cleemann L, Morad M Cardiac progenitor cells engineered with Pim-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes. J. Mol. Cell. Cardiol. 2012 Nov 53(5):695-706. Epub 2012 Aug 19

Cottage CT, Neidig L, Sundararaman B, Din S, Joyo AY, Bailey B, Gude N, Hariharan N, Sussman MA Increased mitotic rate coincident with transient telomere lengthening resulting from pim-1 overexpression in cardiac progenitor cells. Stem Cells 2012 Nov 30(11):2512-22.

Mohsin S, Khan M, Toko H, Bailey B, Cottage CT, Wallach K, Nag D, Lee A, Siddiqi S, Lan F, Fischer KM, Gude N, Quijada P, Avitabile D, Truffa S, Collins B, Dembitsky W, Wu JC, Sussman MA Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. J. Am. Coll. Cardiol. 2012 Oct 02 60(14):1278-87. Epub 2012 Jul 26

Bailey B, Fransioli J, Gude NA, Alvarez R, Zhang X, Zhan X, Gustafsson ÅB, Sussman MA Sca-1 knockout impairs myocardial and cardiac progenitor cell function. Circ. Res. 2012 Aug 31 111(6):750-60. Epub 2012 Jul 16

Quijada P, Toko H, Fischer KM, Bailey B, Reilly P, Hunt KD, Gude NA, Avitabile D, Sussman MA Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells. Circ. Res. 2012 Jun 22 111(1):77-86. Epub 2012 May 22

Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ, Koch W, Animal models of heart failure: a scientific statement from the American Heart Association. Circ. Res. 2012 Jun 22 111(1):131-50. Epub 2012 May 17

Sussman MA Myocardial Isl(+)land: a place with lots of rhythm, but no beat. Circ. Res. 2012 May 11 110(10):1267-9.

Sundararaman B, Avitabile D, Konstandin MH, Cottage CT, Gude N, Sussman MA Asymmetric chromatid segregation in cardiac progenitor cells is enhanced by Pim-1 kinase. Circ. Res. 2012 Apr 27 110(9):1169-73. Epub 2012 Mar 22

Völkers M, Dolatabadi N, Gude N, Most P, Sussman MA, Hassel D Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish. J. Cell. Sci. 2012 Jan 15 125(Pt 2):287-94. Epub 2012 Feb 02

Ruller CM, Tabor-Godwin JM, Van Deren DA, Robinson SM, Maciejewski S, Gluhm S, Gilbert PE, An N, Gude NA, Sussman MA, Whitton JL, Feuer R Neural stem cell depletion and CNS developmental defects after enteroviral infection. Am. J. Pathol. 2012 Mar 180(3):1107-20. Epub 2011 Dec 31

Mohsin S, Siddiqi S, Collins B, Sussman MA Empowering adult stem cells for myocardial regeneration. Circ. Res. 2011 Dec 09 109(12):1415-28.

Sussman MA, Völkers M, Fischer K, Bailey B, Cottage CT, Din S, Gude N, Avitabile D, Alvarez R, Sundararaman B, Quijada P, Mason M, Konstandin MH, Malhowski A, Cheng Z, Khan M, McGregor M Myocardial AKT: the omnipresent nexus. Physiol. Rev. 2011 Jul 91(3):1023-70.

Meloche J, Paulin R, Courboulin A, Lambert C, Barrier M, Bonnet P, Bisserier M, Roy M, Sussman MA, Agharazii M, Bonnet S RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes. Arterioscler. Thromb. Vasc. Biol. 2011 Sep 31(9):2114-24. Epub 2011 Jun 16

Sussman MA Curiosity killed the cat and found new myocytes. Circ. Res. 2011 May 13 108(10):1158-9.

Avitabile D, Bailey B, Cottage CT, Sundararaman B, Joyo A, McGregor M, Gude N, Truffa S, Zarrabi A, Konstandin M, Khan M, Mohsin S, Völkers M, Toko H, Mason M, Cheng Z, Din S, Alvarez R, Fischer K, Sussman MA Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin. Proc. Natl. Acad. Sci. U.S.A. 2011 Apr 12 108(15):6145-50. Epub 2011 Mar 28

Paulin R, Courboulin A, Meloche J, Mainguy V, Dumas de la Roque E, Saksouk N, Côté J, Provencher S, Sussman MA, Bonnet S Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension. Circulation 2011 Mar 22 123(11):1205-15. Epub 2011 Mar 07

Fischer KM, Din S, Gude N, Konstandin MH, Wu W, Quijada P, Sussman MA Cardiac progenitor cell commitment is inhibited by nuclear Akt expression. Circ. Res. 2011 Apr 15 108(8):960-70. Epub 2011 Feb 24

Fischer KM, Cottage CT, Konstandin MH, Völkers M, Khan M, Sussman MA Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling. J. Mol. Cell. Cardiol. 2011 Oct 51(4):554-8. Epub 2011 Jan 19

Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Eur. Heart J. 2011 Sep 32(17):2179-88. Epub 2011 Jan 12

Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ. Res. 2010 Aug 20 107(4):476-84. Epub 2010 Jun 24

Tabor-Godwin JM, Ruller CM, Bagalso N, An N, Pagarigan RR, Harkins S, Gilbert PE, Kiosses WB, Gude NA, Cornell CT, Doran KS, Sussman MA, Whitton JL, Feuer R A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS. J. Neurosci. 2010 Jun 23 30(25):8676-91.

Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ. Res. 2010 Apr 16 106(7):1265-74. Epub 2010 Mar 04

Voelkers M, Salz M, Herzog N, Frank D, Dolatabadi N, Frey N, Gude N, Friedrich O, Koch WJ, Katus HA, Sussman MA, Most P Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes. J. Mol. Cell. Cardiol. 2010 Jun 48(6):1329-34. Epub 2010 Feb 06

Adam O, Lavall D, Theobald K, Hohl M, Grube M, Ameling S, Sussman MA, Rosenkranz S, Kroemer HK, Schäfers HJ, Böhm M, Laufs U Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. J. Am. Coll. Cardiol. 2010 Feb 02 55(5):469-80.

Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation 2010 Feb 09 121(5):675-83. Epub 2010 Jan 25

Cottage CT, Bailey B, Fischer KM, Avitabile D, Avitable D, Collins B, Tuck S, Quijada P, Gude N, Alvarez R, Muraski J, Sussman MA Cardiac progenitor cell cycling stimulated by pim-1 kinase. Circ. Res. 2010 Mar 19 106(5):891-901. Epub 2010 Jan 14

Belmont PJ, Chen WJ, San Pedro MN, Thuerauf DJ, Gellings Lowe N, Gude N, Hilton B, Wolkowicz R, Sussman MA, Glembotski CC Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart. Circ. Res. 2010 Feb 05 106(2):307-16. Epub 2009 Nov 25

Bailey B, Izarra A, Alvarez R, Fischer KM, Cottage CT, Quijada P, Díez-Juan A, Sussman MA Cardiac stem cell genetic engineering using the alphaMHC promoter. Regen Med 2009 Nov 4(6):823-33.

Fischer KM, Cottage CT, Wu W, Din S, Gude NA, Avitabile D, Quijada P, Collins BL, Fransioli J, Sussman MA Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase. Circulation 2009 Nov 24 120(21):2077-87. Epub 2009 Nov 09

Sussman MA Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte. Expert Rev Cardiovasc Ther 2009 Aug 7(8):929-38.

Miyamoto S, Rubio M, Sussman MA Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc. Res. 2009 May 01 82(2):272-85. Epub 2009 Mar 11

Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown JH, Sussman MA Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. J. Mol. Cell. Cardiol. 2009 Jul 47(1):96-103. Epub 2009 Mar 06

Whittaker R, Glassy MS, Gude N, Sussman MA, Gottlieb RA, Glembotski CC Kinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria during ex vivo ischemia. Am. J. Physiol. Heart Circ. Physiol. 2009 May 296(5):H1633-42. Epub 2009 Feb 27

Sussman MA Developing hearts need their SPEG. Circulation 2009 Jan 20 119(2):213-4.

Sussman MA Showing up isn't enough for vascularization: persistence is essential. Circ. Res. 2008 Nov 21 103(11):1200-1.

McKeown CR, Nowak RB, Moyer J, Sussman MA, Fowler VM Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development. Circ. Res. 2008 Nov 21 103(11):1241-8. Epub 2008 Oct 16

Tadimalla A, Belmont PJ, Thuerauf DJ, Glassy MS, Martindale JJ, Gude N, Sussman MA, Glembotski CC Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart. Circ. Res. 2008 Nov 21 103(11):1249-58. Epub 2008 Oct 16

Muraski JA, Fischer KM, Wu W, Cottage CT, Quijada P, Mason M, Din S, Gude N, Alvarez R, Rota M, Kajstura J, Wang Z, Schaefer E, Chen X, MacDonnel S, Magnuson N, Houser SR, Anversa P, Sussman MA Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proc. Natl. Acad. Sci. U.S.A. 2008 Sep 16 105(37):13889-94. Epub 2008 Sep 10

Siddiqi S, Gude N, Hosoda T, Muraski J, Rubio M, Emmanuel G, Fransioli J, Vitale S, Parolin C, D'Amario D, Schaefer E, Kajstura J, Leri A, Anversa P, Sussman MA Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ. Res. 2008 Jul 03 103(1):89-97. Epub 2008 Jun 02

Sussman MA, Murry CE Bones of contention: marrow-derived cells in myocardial regeneration. J. Mol. Cell. Cardiol. 2008 Jun 44(6):950-3. Epub 2008 Mar 15

Gude NA, Emmanuel G, Wu W, Cottage CT, Fischer K, Quijada P, Muraski JA, Alvarez R, Rubio M, Schaefer E, Sussman MA Activation of Notch-mediated protective signaling in the myocardium. Circ. Res. 2008 May 09 102(9):1025-35. Epub 2008 Mar 27

Belmont PJ, Tadimalla A, Chen WJ, Martindale JJ, Thuerauf DJ, Marcinko M, Gude N, Sussman MA, Glembotski CC Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene. J. Biol. Chem. 2008 May 16 283(20):14012-21. Epub 2008 Mar 03

Fransioli J, Bailey B, Gude NA, Cottage CT, Muraski JA, Emmanuel G, Wu W, Alvarez R, Rubio M, Ottolenghi S, Schaefer E, Sussman MA Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells 2008 May 26(5):1315-24. Epub 2008 Feb 28

Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat. Med. 2007 Dec 13(12):1467-75. Epub 2007 Nov 25

Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, Iaffaldano G, Padin-Iruegas ME, Gonzalez A, Rizzi R, Small N, Muraski J, Alvarez R, Chen X, Urbanek K, Bolli R, Houser SR, Leri A, Sussman MA, Anversa P Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc. Natl. Acad. Sci. U.S.A. 2007 Nov 06 104(45):17783-8. Epub 2007 Oct 26

Adam O, Frost G, Custodis F, Sussman MA, Schäfers HJ, Böhm M, Laufs U Role of Rac1 GTPase activation in atrial fibrillation. J. Am. Coll. Cardiol. 2007 Jul 24 50(4):359-67. Epub 2007 Jul 06

Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc. Natl. Acad. Sci. U.S.A. 2006 Aug 08 103(32):11946-51. Epub 2006 Aug 01

Gude N, Muraski J, Rubio M, Kajstura J, Schaefer E, Anversa P, Sussman MA Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ. Res. 2006 Aug 18 99(4):381-8. Epub 2006 Jul 13

Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, Glembotski CC Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ. Res. 2006 Aug 04 99(3):275-82. Epub 2006 Jun 22

Martindale JJ, Fernandez R, Thuerauf D, Whittaker R, Gude N, Sussman MA, Glembotski CC Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ. Res. 2006 May 12 98(9):1186-93. Epub 2006 Apr 06

Sussman MA Cause of death: a "broken" MEKK? J. Mol. Cell. Cardiol. 2006 May 40(5):593-6. Epub 2006 Apr 04

Brown JH, Del Re DP, Sussman MA The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ. Res. 2006 Mar 31 98(6):730-42.

Rota M, Boni A, Urbanek K, Padin-Iruegas ME, Kajstura TJ, Fiore G, Kubo H, Sonnenblick EH, Musso E, Houser SR, Leri A, Sussman MA, Anversa P Nuclear targeting of Akt enhances ventricular function and myocyte contractility. Circ. Res. 2005 Dec 09 97(12):1332-41. Epub 2005 Nov 17

Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J. Clin. Invest. 2005 Oct 115(10):2716-30.

Buscemi N, Murray C, Doherty-Kirby A, Lajoie G, Sussman MA, Van Eyk JE Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 2005 Dec 289(6):H2325-33. Epub 2005 Sep 09

Plank DM, Sussman MA Impaired intracellular Ca2+ dynamics in live cardiomyocytes revealed by rapid line scan confocal microscopy. Microsc. Microanal. 2005 Jun 11(3):235-43.

Steinberg SF, Sussman MA Cardiac hypertrophy served with protein kinase Cepsilon: delta isoform substitution available at additional cost. Circ. Res. 2005 Apr 15 96(7):711-3.

Plank DM, Sussman MA Intracellular Ca2+ measurements in live cells by rapid line scan confocal microscopy: simplified calibration methodology. Methods Cell Sci 2003 25(3-4):123-33.

Tsujita Y, Kato T, Sussman MA Evaluation of left ventricular function in cardiomyopathic mice by tissue Doppler and color M-mode Doppler echocardiography. Echocardiography 2005 Mar 22(3):245-53.

Melendez J, Turner C, Avraham H, Steinberg SF, Schaefer E, Sussman MA Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J. Biol. Chem. 2004 Dec 17 279(51):53516-23. Epub 2004 Aug 22

Anversa P, Sussman MA, Bolli R Molecular genetic advances in cardiovascular medicine: focus on the myocyte. Circulation 2004 Jun 15 109(23):2832-8.

Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ. Res. 2004 Apr 16 94(7):884-91. Epub 2004 Feb 26

Sussman MA, Anversa P Myocardial aging and senescence: where have the stem cells gone? Annu. Rev. Physiol. 2004 66:29-48.

Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ. Res. 2004 Mar 05 94(4):514-24. Epub 2004 Jan 15

Buscemi N, Doherty-Kirby A, Sussman MA, Lajoie G, Van Eyk JE Proteomic analysis of Rac1 transgenic mice displaying dilated cardiomyopathy reveals an increase in creatine kinase M-chain protein abundance. Mol. Cell. Biochem. 2003 Sep 251(1-2):145-51.

Sussman MA ICER-capades: putting cardiac cyclic AMP signaling "on ice". Circ. Res. 2003 Jul 11 93(1):6-8.

Plank DM, Yatani A, Ritsu H, Witt S, Glascock B, Lalli MJ, Periasamy M, Fiset C, Benkusky N, Valdivia HH, Sussman MA Calcium dynamics in the failing heart: restoration by beta-adrenergic receptor blockade. Am. J. Physiol. Heart Circ. Physiol. 2003 Jul 285(1):H305-15. Epub 2003 Mar 20

Sussman MA, McCulloch A, Borg TK Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy. Circ. Res. 2002 Nov 15 91(10):888-98.

Sayen MR, Gustafsson AB, Sussman MA, Molkentin JD, Gottlieb RA Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. Am. J. Physiol., Cell Physiol. 2003 Feb 284(2):C562-70. Epub 2002 Oct 23

Melendez J, Welch S, Schaefer E, Moravec CS, Avraham S, Avraham H, Sussman MA Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. J. Biol. Chem. 2002 Nov 22 277(47):45203-10. Epub 2002 Sep 12

Welch S, Plank D, Witt S, Glascock B, Schaefer E, Chimenti S, Andreoli AM, Limana F, Leri A, Kajstura J, Anversa P, Sussman MA Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Circ. Res. 2002 Apr 05 90(6):641-8.

Sussman MA Cellular indigestion: chaperones head to the cytoskeleton. J. Mol. Cell. Cardiol. 2002 Feb 34(2):83-5.

Sussman MA When the thyroid speaks, the heart listens. Circ. Res. 2001 Sep 28 89(7):557-9.

Camper-Kirby D, Welch S, Walker A, Shiraishi I, Setchell KD, Schaefer E, Kajstura J, Anversa P, Sussman MA Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ. Res. 2001 May 25 88(10):1020-7.

Delling U, Sussman MA, Molkentin JD Re-evaluating sarcoplasmic reticulum function in heart failure. Nat. Med. 2000 Sep 6(9):942-3.

Babu GJ, Lalli MJ, Sussman MA, Sadoshima J, Periasamy M Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J. Mol. Cell. Cardiol. 2000 Aug 32(8):1447-57.

Lim HW, De Windt LJ, Mante J, Kimball TR, Witt SA, Sussman MA, Molkentin JD Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition. J. Mol. Cell. Cardiol. 2000 Apr 32(4):697-709.

Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Price RL, Schaefer E, Yager K Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. J. Clin. Invest. 2000 Apr 105(7):875-86.

Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Witt SA, Kimball TR, Price R, Lim HW, Molkentin JD Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice. Cardiovasc. Res. 2000 Apr 46(1):90-101.

Yang J, Moravec CS, Sussman MA, DiPaola NR, Fu D, Hawthorn L, Mitchell CA, Young JB, Francis GS, McCarthy PM, Bond M Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays. Circulation 2000 Dec 19 102(25):3046-52.

Sussman MA, Welch S, Gude N, Khoury PR, Daniels SR, Kirkpatrick D, Walsh RA, Price RL, Lim HW, Molkentin JD Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice. Am. J. Pathol. 1999 Dec 155(6):2101-13.

Sussman MA, Lim HW, Gude N, Taigen T, Olson EN, Robbins J, Colbert MC, Gualberto A, Wieczorek DF, Molkentin JD Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science 1998 Sep 11 281(5383):1690-3.

Sussman MA, Welch S, Cambon N, Klevitsky R, Hewett TE, Price R, Witt SA, Kimball TR Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice. J. Clin. Invest. 1998 Jan 01 101(1):51-61.

Sussman MA, Baqué S, Uhm CS, Daniels MP, Price RL, Simpson D, Terracio L, Kedes L Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils. Circ. Res. 82(1):94-105.

Sussman MA, Hamm-Alvarez SF, Vilalta PM, Welch S, Kedes L Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis. Circ. Res. 1997 Jan 80(1):52-61.

Sussman MA, McAvoy JW, Rudisill M, Swanson B, Lyons GE, Kedes L, Blanks J Lens tropomodulin: developmental expression during differentiation. Exp. Eye Res. 1996 Aug 63(2):223-32.

Sussman MA, Ito M, Daniels MP, Flucher B, Buranen S, Kedes L Chicken skeletal muscle tropomodulin: novel localization and characterization. Cell Tissue Res. 1996 Aug 285(2):287-96.

Przyklenk K, Sussman MA, Simkhovich BZ, Kloner RA Does ischemic preconditioning trigger translocation of protein kinase C in the canine model? Circulation 1995 Sep 15 92(6):1546-57.

Ito M, Swanson B, Sussman MA, Kedes L, Lyons G Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis. Dev. Biol. 1995 Jan 167(1):317-28.

Sussman MA, Sakhi S, Barrientos P, Ito M, Kedes L Tropomodulin in rat cardiac muscle. Localization of protein is independent of messenger RNA distribution during myofibrillar development. Circ. Res. 1994 Aug 75(2):221-32.

Sussman MA, Sakhi S, Tocco G, Najm I, Baudry M, Kedes L, Schreiber SS Neural tropomodulin: developmental expression and effect of seizure activity. Brain Res. Dev. Brain Res. 1994 Jul 15 80(1-2):45-53.

Sussman MA, Bilak M, Kedes L, Engel WK, Askanas V Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions. Exp. Cell Res. 1993 Dec 209(2):388-91.

Sussman MA, Fowler VM Tropomodulin binding to tropomyosins. Isoform-specific differences in affinity and stoichiometry. Eur. J. Biochem. 1992 Apr 01 205(1):355-62.

Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. J. Biol. Chem. 1992 Feb 05 267(4):2616-21.

Shubin RA, Sussman MA, Fleming JO, Stohlman SA Relapsing encephalomyelitis following transfer of partial immunity to JHM virus. Microb. Pathog. 1990 May 8(5):305-14.

Sussman MA, Battenberg E, Bloom FE, Fowler VM Identification of two nerve growth factor-induced polypeptides in PC12 cells. J. Mol. Neurosci. 1990 2(3):163-74.

Sussman MA, Shubin RA, Kyuwa S, Stohlman SA T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system. J. Virol. 1989 Jul 63(7):3051-6.

Fleming JO, Shubin RA, Sussman MA, Casteel N, Stohlman SA Monoclonal antibodies to the matrix (E1) glycoprotein of mouse hepatitis virus protect mice from encephalitis. Virology 1989 Jan 168(1):162-7.

Stohlman SA, Sussman MA, Matsushima GK, Shubin RA, Erlich SS Delayed-type hypersensitivity response in the central nervous system during JHM virus infection requires viral specificity for protection. J. Neuroimmunol. 1988 Sep 19(3):255-68.

Sussman MA, Fleming JO, Allen H, Stohlman SA Immune mediated clearance of JHM virus from the central nervous system. Adv. Exp. Med. Biol. 1987 218:399-410.