Publications

Fischer KM, Cottage CT, Wu W, Din S, Gude NA, Avitabile D, Quijada P, Collins BL, Fransioli J, Sussman MA Enhancement of Myocardial Regeneration Through Genetic Engineering of Cardiac Progenitor Cells Expressing Pim-1 Kinase. Circulation 2009 Nov 9 Epub 2009 Nov 9

Bailey B, Izarra A, Alvarez R, Fischer KM, Cottage CT, Quijada P, Díez-Juan A, Sussman MA Cardiac stem cell genetic engineering using the alphaMHC promoter. Regen Med 2009 Nov 4(6):823-33.

Sussman MA Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte. Expert Rev Cardiovasc Ther 2009 Aug 7(8):929-38.

Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown JH, Sussman MA Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. J Mol Cell Cardiol 2009 Jul 47(1):96-103. Epub 2009 Mar 06

Whittaker R, Glassy MS, Gude N, Sussman MA, Gottlieb RA, Glembotski CC Kinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria during ex vivo ischemia. Am J Physiol Heart Circ Physiol 2009 May 296(5):H1633-42. Epub 2009 Feb 27

Miyamoto S, Rubio M, Sussman MA Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res 2009 May 1 82(2):272-85. Epub 2009 Mar 11

Sussman MA Developing hearts need their SPEG. Circulation 2009 Jan 20 119(2):213-4.

Sussman MA Showing up isn't enough for vascularization: persistence is essential. Circ Res 2008 Nov 21 103(11):1200-1.

McKeown CR, Nowak RB, Moyer J, Sussman MA, Fowler VM Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development. Circ Res 2008 Nov 21 103(11):1241-8. Epub 2008 Oct 16

Tadimalla A, Belmont PJ, Thuerauf DJ, Glassy MS, Martindale JJ, Gude N, Sussman MA, Glembotski CC Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart. Circ Res 2008 Nov 21 103(11):1249-58. Epub 2008 Oct 16

Muraski JA, Fischer KM, Wu W, Cottage CT, Quijada P, Mason M, Din S, Gude N, Alvarez R, Rota M, Kajstura J, Wang Z, Schaefer E, Chen X, MacDonnel S, Magnuson N, Houser SR, Anversa P, Sussman MA Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proc Natl Acad Sci U S A 2008 Sep 16 105(37):13889-94. Epub 2008 Sep 10

Siddiqi S, Gude N, Hosoda T, Muraski J, Rubio M, Emmanuel G, Fransioli J, Vitale S, Parolin C, D'Amario D, Schaefer E, Kajstura J, Leri A, Anversa P, Sussman MA Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ Res 2008 Jul 3 103(1):89-97. Epub 2008 Jun 02

Sussman MA, Murry CE Bones of contention: marrow-derived cells in myocardial regeneration. J Mol Cell Cardiol 2008 Jun 44(6):950-3. Epub 2008 Mar 15

Belmont PJ, Tadimalla A, Chen WJ, Martindale JJ, Thuerauf DJ, Marcinko M, Gude N, Sussman MA, Glembotski CC Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene. J Biol Chem 2008 May 16 283(20):14012-21. Epub 2008 Mar 03

Gude NA, Emmanuel G, Wu W, Cottage CT, Fischer K, Quijada P, Muraski JA, Alvarez R, Rubio M, Schaefer E, Sussman MA Activation of Notch-mediated protective signaling in the myocardium. Circ Res 2008 May 9 102(9):1025-35. Epub 2008 Mar 27

Fransioli J, Bailey B, Gude NA, Cottage CT, Muraski JA, Emmanuel G, Wu W, Alvarez R, Rubio M, Ottolenghi S, Schaefer E, Sussman MA Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells 2008 May 26(5):1315-24. Epub 2008 Feb 28

Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med 2007 Dec 13(12):1467-75. Epub 2007 Nov 25

Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, Iaffaldano G, Padin-Iruegas ME, Gonzalez A, Rizzi R, Small N, Muraski J, Alvarez R, Chen X, Urbanek K, Bolli R, Houser SR, Leri A, Sussman MA, Anversa P Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A 2007 Nov 6 104(45):17783-8. Epub 2007 Oct 26

Adam O, Frost G, Custodis F, Sussman MA, Schäfers HJ, Böhm M, Laufs U Role of Rac1 GTPase activation in atrial fibrillation. J Am Coll Cardiol 2007 Jul 24 50(4):359-67. Epub 2007 Jul 06

Gude N, Muraski J, Rubio M, Kajstura J, Schaefer E, Anversa P, Sussman MA Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res 2006 Aug 18 99(4):381-8. Epub 2006 Jul 13

Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A 2006 Aug 8 103(32):11946-51. Epub 2006 Aug 01

Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, Glembotski CC Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ Res 2006 Aug 4 99(3):275-82. Epub 2006 Jun 22

Martindale JJ, Fernandez R, Thuerauf D, Whittaker R, Gude N, Sussman MA, Glembotski CC Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ Res 2006 May 12 98(9):1186-93. Epub 2006 Apr 06

Sussman MA Cause of death: a "broken" MEKK? J Mol Cell Cardiol 2006 May 40(5):593-6. Epub 2006 Apr 04

Brown JH, Del Re DP, Sussman MA The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ Res 2006 Mar 31 98(6):730-42.

Rota M, Boni A, Urbanek K, Padin-Iruegas ME, Kajstura TJ, Fiore G, Kubo H, Sonnenblick EH, Musso E, Houser SR, Leri A, Sussman MA, Anversa P Nuclear targeting of Akt enhances ventricular function and myocyte contractility. Circ Res 2005 Dec 9 97(12):1332-41. Epub 2005 Nov 17

Buscemi N, Murray C, Doherty-Kirby A, Lajoie G, Sussman MA, Van Eyk JE Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy. Am J Physiol Heart Circ Physiol 2005 Dec 289(6):H2325-33. Epub 2005 Sep 09

Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest 2005 Oct 115(10):2716-30.

Plank DM, Sussman MA Impaired intracellular Ca2+ dynamics in live cardiomyocytes revealed by rapid line scan confocal microscopy. Microsc Microanal 2005 Jun 11(3):235-43.

Steinberg SF, Sussman MA Cardiac hypertrophy served with protein kinase Cepsilon: delta isoform substitution available at additional cost. Circ Res 2005 Apr 15 96(7):711-3.

Tsujita Y, Kato T, Sussman MA Evaluation of left ventricular function in cardiomyopathic mice by tissue Doppler and color M-mode Doppler echocardiography. Echocardiography 2005 Mar 22(3):245-53.

Melendez J, Turner C, Avraham H, Steinberg SF, Schaefer E, Sussman MA Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem 2004 Dec 17 279(51):53516-23. Epub 2004 Aug 22

Anversa P, Sussman MA, Bolli R Molecular genetic advances in cardiovascular medicine: focus on the myocyte. Circulation 2004 Jun 15 109(23):2832-8.

Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res 2004 Apr 16 94(7):884-91. Epub 2004 Feb 26

Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res 2004 Mar 5 94(4):514-24. Epub 2004 Jan 15

Sussman MA, Anversa P Myocardial aging and senescence: where have the stem cells gone? Annu Rev Physiol 2004 66:29-48.

Buscemi N, Doherty-Kirby A, Sussman MA, Lajoie G, Van Eyk JE Proteomic analysis of Rac1 transgenic mice displaying dilated cardiomyopathy reveals an increase in creatine kinase M-chain protein abundance. Mol Cell Biochem 2003 Sep 251(1-2):145-51.

Sussman MA ICER-capades: putting cardiac cyclic AMP signaling "on ice". Circ Res 2003 Jul 11 93(1):6-8.

Plank DM, Yatani A, Ritsu H, Witt S, Glascock B, Lalli MJ, Periasamy M, Fiset C, Benkusky N, Valdivia HH, Sussman MA Calcium dynamics in the failing heart: restoration by beta-adrenergic receptor blockade. Am J Physiol Heart Circ Physiol 2003 Jul 285(1):H305-15. Epub 2003 Mar 20

Sayen MR, Gustafsson AB, Sussman MA, Molkentin JD, Gottlieb RA Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. Am J Physiol Cell Physiol 2003 Feb 284(2):C562-70. Epub 2002 Oct 23

Plank DM, Sussman MA Intracellular Ca2+ measurements in live cells by rapid line scan confocal microscopy: simplified calibration methodology. Methods Cell Sci 2003 25(3-4):123-33.

Melendez J, Welch S, Schaefer E, Moravec CS, Avraham S, Avraham H, Sussman MA Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. J Biol Chem 2002 Nov 22 277(47):45203-10. Epub 2002 Sep 12

Sussman MA, McCulloch A, Borg TK Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy. Circ Res 2002 Nov 15 91(10):888-98.

Welch S, Plank D, Witt S, Glascock B, Schaefer E, Chimenti S, Andreoli AM, Limana F, Leri A, Kajstura J, Anversa P, Sussman MA Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Circ Res 2002 Apr 5 90(6):641-8.

Sussman MA Cellular indigestion: chaperones head to the cytoskeleton. J Mol Cell Cardiol 2002 Feb 34(2):83-5.

Sussman MA When the thyroid speaks, the heart listens. Circ Res 2001 Sep 28 89(7):557-9.

Camper-Kirby D, Welch S, Walker A, Shiraishi I, Setchell KD, Schaefer E, Kajstura J, Anversa P, Sussman MA Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res 2001 May 25 88(10):1020-7.

Yang J, Moravec CS, Sussman MA, DiPaola NR, Fu D, Hawthorn L, Mitchell CA, Young JB, Francis GS, McCarthy PM, Bond M Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays. Circulation 2000 Dec 19 102(25):3046-52.

Delling U, Sussman MA, Molkentin JD Re-evaluating sarcoplasmic reticulum function in heart failure. Nat Med 2000 Sep 6(9):942-3.

Babu GJ, Lalli MJ, Sussman MA, Sadoshima J, Periasamy M Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol 2000 Aug 32(8):1447-57.

Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Witt SA, Kimball TR, Price R, Lim HW, Molkentin JD Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice. Cardiovasc Res 2000 Apr 46(1):90-101.

Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Price RL, Schaefer E, Yager K Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. J Clin Invest 2000 Apr 105(7):875-86.

Lim HW, De Windt LJ, Mante J, Kimball TR, Witt SA, Sussman MA, Molkentin JD Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition. J Mol Cell Cardiol 2000 Apr 32(4):697-709.

Sussman MA, Welch S, Gude N, Khoury PR, Daniels SR, Kirkpatrick D, Walsh RA, Price RL, Lim HW, Molkentin JD Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice. Am J Pathol 1999 Dec 155(6):2101-13.

Sussman MA, Lim HW, Gude N, Taigen T, Olson EN, Robbins J, Colbert MC, Gualberto A, Wieczorek DF, Molkentin JD Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science 1998 Sep 11 281(5383):1690-3.

Sussman MA, Baqué S, Uhm CS, Daniels MP, Price RL, Simpson D, Terracio L, Kedes L Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils. Circ Res 82(1):94-105.

Sussman MA, Welch S, Cambon N, Klevitsky R, Hewett TE, Price R, Witt SA, Kimball TR Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice. J Clin Invest 1998 Jan 1 101(1):51-61.

Sussman MA, Hamm-Alvarez SF, Vilalta PM, Welch S, Kedes L Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis. Circ Res 1997 Jan 80(1):52-61.

Sussman MA, Ito M, Daniels MP, Flucher B, Buranen S, Kedes L Chicken skeletal muscle tropomodulin: novel localization and characterization. Cell Tissue Res 1996 Aug 285(2):287-96.

Sussman MA, McAvoy JW, Rudisill M, Swanson B, Lyons GE, Kedes L, Blanks J Lens tropomodulin: developmental expression during differentiation. Exp Eye Res 1996 Aug 63(2):223-32.

Przyklenk K, Sussman MA, Simkhovich BZ, Kloner RA Does ischemic preconditioning trigger translocation of protein kinase C in the canine model? Circulation 1995 Sep 15 92(6):1546-57.

Ito M, Swanson B, Sussman MA, Kedes L, Lyons G Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis. Dev Biol 1995 Jan 167(1):317-28.

Sussman MA, Sakhi S, Barrientos P, Ito M, Kedes L Tropomodulin in rat cardiac muscle. Localization of protein is independent of messenger RNA distribution during myofibrillar development. Circ Res 1994 Aug 75(2):221-32.

Sussman MA, Sakhi S, Tocco G, Najm I, Baudry M, Kedes L, Schreiber SS Neural tropomodulin: developmental expression and effect of seizure activity. Brain Res Dev Brain Res 1994 Jul 15 80(1-2):45-53.

Sussman MA, Bilak M, Kedes L, Engel WK, Askanas V Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions. Exp Cell Res 1993 Dec 209(2):388-91.

Sussman MA, Fowler VM Tropomodulin binding to tropomyosins. Isoform-specific differences in affinity and stoichiometry. Eur J Biochem 1992 Apr 1 205(1):355-62.

Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. J Biol Chem 1992 Feb 5 267(4):2616-21.

Shubin RA, Sussman MA, Fleming JO, Stohlman SA Relapsing encephalomyelitis following transfer of partial immunity to JHM virus. Microb Pathog 1990 May 8(5):305-14.

Sussman MA, Battenberg E, Bloom FE, Fowler VM Identification of two nerve growth factor-induced polypeptides in PC12 cells. J Mol Neurosci 1990 2(3):163-74.

Sussman MA, Shubin RA, Kyuwa S, Stohlman SA T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system. J Virol 1989 Jul 63(7):3051-6.

Fleming JO, Shubin RA, Sussman MA, Casteel N, Stohlman SA Monoclonal antibodies to the matrix (E1) glycoprotein of mouse hepatitis virus protect mice from encephalitis. Virology 1989 Jan 168(1):162-7.

Stohlman SA, Sussman MA, Matsushima GK, Shubin RA, Erlich SS Delayed-type hypersensitivity response in the central nervous system during JHM virus infection requires viral specificity for protection. J Neuroimmunol 1988 Sep 19(3):255-68.

Sussman MA, Fleming JO, Allen H, Stohlman SA Immune mediated clearance of JHM virus from the central nervous system. Adv Exp Med Biol 1987 218:399-410.