Broughton KM, Sussman MA.Empowering Adult Stem Cells for Myocardial Regeneration V2.0: Success in Small Steps. Circ Res. 2016 Mar 4;118(5):867-80. doi: 10.1161/CIRCRESAHA.115.305227. Review.
PMID: 26941423

Anderson ME, Goldhaber J, Houser SR, Puceat M, Sussman MA Embryonic stem cell-derived cardiac myocytes are not ready for human trials. Circ Res 2014 Jul 18 115(3):335-8. Epub 2014 Jun 16

Din S, Konstandin MH, Johnson B, Emathinger J, Völkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA Metabolic dysfunction consistent with premature aging results from deletion of pim kinases. Circ Res 2014 Jul 18 115(3):376-87. Epub 2014 Jun 10

Sin J, Puccini JM, Huang C, Konstandin MH, Gilbert PE, Sussman MA, Gottlieb RA, Feuer R The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. PLoS Pathog 2014 Jul 10(7):e1004249. Epub 2014 Jul 31

Hariharan N, Sussman MA Pin1: A molecular orchestrator in the heart. Trends Cardiovasc Med 2014 Jun 4 Epub 2014 Jun 4

Hariharan N, Sussman MA Stressing on the nucleolus in cardiovascular disease. Biochim Biophys Acta 2014 Jun 1842(6):798-801. Epub 2013 Oct 24

McGregor M, Hariharan N, Joyo AY, Margolis RL, Sussman MA CENP-A is essential for cardiac progenitor cell proliferation. Cell Cycle 2014 Mar 1 13(5):739-48. Epub 2013 Dec 20

Toko H, Hariharan N, Konstandin MH, Ormachea L, McGregor M, Gude NA, Sundararaman B, Joyo E, Joyo AY, Collins B, Din S, Mohsin S, Uchida T, Sussman MA Differential regulation of cellular senescence and differentiation by prolyl isomerase Pin1 in cardiac progenitor cells. J Biol Chem 2014 Feb 28 289(9):5348-56. Epub 2013 Dec 27

Mohsin S, Wu JC, Sussman MA Predicting the future with stem cells. Circulation 2014 Jan 14 129(2):136-8. Epub 2013 Nov 18

Völkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity. EMBO Mol Med 2014 Jan 6(1):57-65.

Khan M, Mohsin S, Toko H, Alkatib M, Nguyen J, Truffa S, Gude N, Chuprun K, Tilley DG, Koch WJ, Sussman MA Cardiac progenitor cells engineered with ?ARKct have enhanced ?-adrenergic tolerance. Mol Ther 2014 Jan 22(1):178-85. Epub 2013 Sep 03

Siddiqi S, Sussman MA Cardiac Hegemony of Senescence. Curr Transl Geriatr Exp Gerontol Rep 2013 Dec 2(4)

Völkers M, Konstandin MH, Doroudgar S, Toko H, Quijada P, Din S, Joyo A, Ornelas L, Samse K, Thuerauf DJ, Gude N, Glembotski CC, Sussman MA Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage. Circulation 2013 Nov 5 128(19):2132-44. Epub 2013 Sep 05

Mohsin S, Khan M, Nguyen J, Alkatib M, Siddiqi S, Hariharan N, Wallach K, Monsanto M, Gude N, Dembitsky W, Sussman MA Rejuvenation of human cardiac progenitor cells with Pim-1 kinase. Circ Res 2013 Oct 25 113(10):1169-79. Epub 2013 Sep 17

Konstandin MH, Völkers M, Collins B, Quijada P, Quintana M, De La Torre A, Ormachea L, Din S, Gude N, Toko H, Sussman MA Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth. Basic Res Cardiol 2013 Sep 108(5):375. Epub 2013 Aug 04

Siddiqi S, Sussman MA Cell and gene therapy for severe heart failure patients: the time and place for Pim-1 kinase. Expert Rev Cardiovasc Ther 2013 Aug 11(8):949-57.

Völkers M, Toko H, Doroudgar S, Din S, Quijada P, Joyo AY, Ornelas L, Joyo E, Thuerauf DJ, Konstandin MH, Gude N, Glembotski CC, Sussman MA Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1. Proc Natl Acad Sci U S A 2013 Jul 30 110(31):12661-6. Epub 2013 Jul 10

Konstandin MH, Toko H, Gastelum GM, Quijada P, De La Torre A, Quintana M, Collins B, Din S, Avitabile D, Völkers M, Gude N, Fässler R, Sussman MA Fibronectin is essential for reparative cardiac progenitor cell response after myocardial infarction. Circ Res 2013 Jul 5 113(2):115-25. Epub 2013 May 07

Thomas RL, Roberts DJ, Kubli DA, Lee Y, Quinsay MN, Owens JB, Fischer KM, Sussman MA, Miyamoto S, Gustafsson ÅB Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure. Genes Dev 2013 Jun 15 27(12):1365-77.

Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, Uchida T, Sussman MA Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circ Res 2013 Apr 26 112(9):1244-52. Epub 2013 Mar 13

Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, Joyo AY, Quijada P, Erhardt P, Magnuson NS, Konstandin MH, Sussman MA Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proc Natl Acad Sci U S A 2013 Apr 9 110(15):5969-74. Epub 2013 Mar 25

Khan M, Mohsin S, Avitabile D, Siddiqi S, Nguyen J, Wallach K, Quijada P, McGregor M, Gude N, Alvarez R, Tilley DG, Koch WJ, Sussman MA ?-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation. Circ Res 2013 Feb 1 112(3):476-86. Epub 2012 Dec 14

Williams AR, Hatzistergos KE, Addicott B, McCall F, Carvalho D, Suncion V, Morales AR, Da Silva J, Sussman MA, Heldman AW, Hare JM Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. Circulation 2013 Jan 15 127(2):213-23. Epub 2012 Dec 05

Tufan H, Zhang XH, Haghshenas N, Sussman MA, Cleemann L, Morad M Cardiac progenitor cells engineered with Pim-1 (CPCeP) develop cardiac phenotypic electrophysiological properties as they are co-cultured with neonatal myocytes. J Mol Cell Cardiol 2012 Nov 53(5):695-706. Epub 2012 Aug 19

Cottage CT, Neidig L, Sundararaman B, Din S, Joyo AY, Bailey B, Gude N, Hariharan N, Sussman MA Increased mitotic rate coincident with transient telomere lengthening resulting from pim-1 overexpression in cardiac progenitor cells. Stem Cells 2012 Nov 30(11):2512-22.

Mohsin S, Khan M, Toko H, Bailey B, Cottage CT, Wallach K, Nag D, Lee A, Siddiqi S, Lan F, Fischer KM, Gude N, Quijada P, Avitabile D, Truffa S, Collins B, Dembitsky W, Wu JC, Sussman MA Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. J Am Coll Cardiol 2012 Oct 2 60(14):1278-87. Epub 2012 Jul 26

Bailey B, Fransioli J, Gude NA, Alvarez R, Zhang X, Zhan X, Gustafsson ÅB, Sussman MA Sca-1 knockout impairs myocardial and cardiac progenitor cell function. Circ Res 2012 Aug 31 111(6):750-60. Epub 2012 Jul 16

Quijada P, Toko H, Fischer KM, Bailey B, Reilly P, Hunt KD, Gude NA, Avitabile D, Sussman MA Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells. Circ Res 2012 Jun 22 111(1):77-86. Epub 2012 May 22

Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ, Koch W, Animal models of heart failure: a scientific statement from the American Heart Association. Circ Res 2012 Jun 22 111(1):131-50. Epub 2012 May 17

Sussman MA Myocardial Isl(+)land: a place with lots of rhythm, but no beat. Circ Res 2012 May 11 110(10):1267-9.

Sundararaman B, Avitabile D, Konstandin MH, Cottage CT, Gude N, Sussman MA Asymmetric chromatid segregation in cardiac progenitor cells is enhanced by Pim-1 kinase. Circ Res 2012 Apr 27 110(9):1169-73. Epub 2012 Mar 22

Ruller CM, Tabor-Godwin JM, Van Deren DA, Robinson SM, Maciejewski S, Gluhm S, Gilbert PE, An N, Gude NA, Sussman MA, Whitton JL, Feuer R Neural stem cell depletion and CNS developmental defects after enteroviral infection. Am J Pathol 2012 Mar 180(3):1107-20. Epub 2011 Dec 31

Völkers M, Dolatabadi N, Gude N, Most P, Sussman MA, Hassel D Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish. J Cell Sci 2012 Jan 15 125(Pt 2):287-94. Epub 2012 Feb 02

Mohsin S, Siddiqi S, Collins B, Sussman MA Empowering adult stem cells for myocardial regeneration. Circ Res 2011 Dec 9 109(12):1415-28.

Fischer KM, Cottage CT, Konstandin MH, Völkers M, Khan M, Sussman MA Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling. J Mol Cell Cardiol 2011 Oct 51(4):554-8. Epub 2011 Jan 19

Meloche J, Paulin R, Courboulin A, Lambert C, Barrier M, Bonnet P, Bisserier M, Roy M, Sussman MA, Agharazii M, Bonnet S RAGE-dependent activation of the oncoprotein Pim1 plays a critical role in systemic vascular remodeling processes. Arterioscler Thromb Vasc Biol 2011 Sep 31(9):2114-24. Epub 2011 Jun 16

Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Eur Heart J 2011 Sep 32(17):2179-88. Epub 2011 Jan 12

Sussman MA, Völkers M, Fischer K, Bailey B, Cottage CT, Din S, Gude N, Avitabile D, Alvarez R, Sundararaman B, Quijada P, Mason M, Konstandin MH, Malhowski A, Cheng Z, Khan M, McGregor M Myocardial AKT: the omnipresent nexus. Physiol Rev 2011 Jul 91(3):1023-70.

Sussman MA Curiosity killed the cat and found new myocytes. Circ Res 2011 May 13 108(10):1158-9.

Fischer KM, Din S, Gude N, Konstandin MH, Wu W, Quijada P, Sussman MA Cardiac progenitor cell commitment is inhibited by nuclear Akt expression. Circ Res 2011 Apr 15 108(8):960-70. Epub 2011 Feb 24

Avitabile D, Bailey B, Cottage CT, Sundararaman B, Joyo A, McGregor M, Gude N, Truffa S, Zarrabi A, Konstandin M, Khan M, Mohsin S, Völkers M, Toko H, Mason M, Cheng Z, Din S, Alvarez R, Fischer K, Sussman MA Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin. Proc Natl Acad Sci U S A 2011 Apr 12 108(15):6145-50. Epub 2011 Mar 28

Paulin R, Courboulin A, Meloche J, Mainguy V, Dumas de la Roque E, Saksouk N, Côté J, Provencher S, Sussman MA, Bonnet S Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension. Circulation 2011 Mar 22 123(11):1205-15. Epub 2011 Mar 07

Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res 2010 Aug 20 107(4):476-84. Epub 2010 Jun 24

Tabor-Godwin JM, Ruller CM, Bagalso N, An N, Pagarigan RR, Harkins S, Gilbert PE, Kiosses WB, Gude NA, Cornell CT, Doran KS, Sussman MA, Whitton JL, Feuer R A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS. J Neurosci 2010 Jun 23 30(25):8676-91.

Voelkers M, Salz M, Herzog N, Frank D, Dolatabadi N, Frey N, Gude N, Friedrich O, Koch WJ, Katus HA, Sussman MA, Most P Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes. J Mol Cell Cardiol 2010 Jun 48(6):1329-34. Epub 2010 Feb 06

Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res 2010 Apr 16 106(7):1265-74. Epub 2010 Mar 04

Cottage CT, Bailey B, Fischer KM, Avitable D, Collins B, Tuck S, Quijada P, Gude N, Alvarez R, Muraski J, Sussman MA Cardiac progenitor cell cycling stimulated by pim-1 kinase. Circ Res 2010 Mar 19 106(5):891-901. Epub 2010 Jan 14

Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation 2010 Feb 9 121(5):675-83. Epub 2010 Jan 25

Belmont PJ, Chen WJ, San Pedro MN, Thuerauf DJ, Gellings Lowe N, Gude N, Hilton B, Wolkowicz R, Sussman MA, Glembotski CC Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart. Circ Res 2010 Feb 5 106(2):307-16. Epub 2009 Nov 25

Adam O, Lavall D, Theobald K, Hohl M, Grube M, Ameling S, Sussman MA, Rosenkranz S, Kroemer HK, Schäfers HJ, Böhm M, Laufs U Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. J Am Coll Cardiol 2010 Feb 2 55(5):469-80.

Fischer KM, Cottage CT, Wu W, Din S, Gude NA, Avitabile D, Quijada P, Collins BL, Fransioli J, Sussman MA Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase. Circulation 2009 Nov 24 120(21):2077-87. Epub 2009 Nov 09

Bailey B, Izarra A, Alvarez R, Fischer KM, Cottage CT, Quijada P, Díez-Juan A, Sussman MA Cardiac stem cell genetic engineering using the alphaMHC promoter. Regen Med 2009 Nov 4(6):823-33.

Sussman MA Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte. Expert Rev Cardiovasc Ther 2009 Aug 7(8):929-38.

Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown JH, Sussman MA Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. J Mol Cell Cardiol 2009 Jul 47(1):96-103. Epub 2009 Mar 06

Whittaker R, Glassy MS, Gude N, Sussman MA, Gottlieb RA, Glembotski CC Kinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria during ex vivo ischemia. Am J Physiol Heart Circ Physiol 2009 May 296(5):H1633-42. Epub 2009 Feb 27

Miyamoto S, Rubio M, Sussman MA Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res 2009 May 1 82(2):272-85. Epub 2009 Mar 11

Sussman MA Developing hearts need their SPEG. Circulation 2009 Jan 20 119(2):213-4.

Sussman MA Showing up isn’t enough for vascularization: persistence is essential. Circ Res 2008 Nov 21 103(11):1200-1.

McKeown CR, Nowak RB, Moyer J, Sussman MA, Fowler VM Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development. Circ Res 2008 Nov 21 103(11):1241-8. Epub 2008 Oct 16

Tadimalla A, Belmont PJ, Thuerauf DJ, Glassy MS, Martindale JJ, Gude N, Sussman MA, Glembotski CC Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart. Circ Res 2008 Nov 21 103(11):1249-58. Epub 2008 Oct 16

Muraski JA, Fischer KM, Wu W, Cottage CT, Quijada P, Mason M, Din S, Gude N, Alvarez R, Rota M, Kajstura J, Wang Z, Schaefer E, Chen X, MacDonnel S, Magnuson N, Houser SR, Anversa P, Sussman MA Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proc Natl Acad Sci U S A 2008 Sep 16 105(37):13889-94. Epub 2008 Sep 10

Siddiqi S, Gude N, Hosoda T, Muraski J, Rubio M, Emmanuel G, Fransioli J, Vitale S, Parolin C, D’Amario D, Schaefer E, Kajstura J, Leri A, Anversa P, Sussman MA Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ Res 2008 Jul 3 103(1):89-97. Epub 2008 Jun 02

Sussman MA, Murry CE Bones of contention: marrow-derived cells in myocardial regeneration. J Mol Cell Cardiol 2008 Jun 44(6):950-3. Epub 2008 Mar 15

Belmont PJ, Tadimalla A, Chen WJ, Martindale JJ, Thuerauf DJ, Marcinko M, Gude N, Sussman MA, Glembotski CC Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene. J Biol Chem 2008 May 16 283(20):14012-21. Epub 2008 Mar 03

Gude NA, Emmanuel G, Wu W, Cottage CT, Fischer K, Quijada P, Muraski JA, Alvarez R, Rubio M, Schaefer E, Sussman MA Activation of Notch-mediated protective signaling in the myocardium. Circ Res 2008 May 9 102(9):1025-35. Epub 2008 Mar 27

Fransioli J, Bailey B, Gude NA, Cottage CT, Muraski JA, Emmanuel G, Wu W, Alvarez R, Rubio M, Ottolenghi S, Schaefer E, Sussman MA Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells 2008 May 26(5):1315-24. Epub 2008 Feb 28

Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med 2007 Dec 13(12):1467-75. Epub 2007 Nov 25

Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, Iaffaldano G, Padin-Iruegas ME, Gonzalez A, Rizzi R, Small N, Muraski J, Alvarez R, Chen X, Urbanek K, Bolli R, Houser SR, Leri A, Sussman MA, Anversa P Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A 2007 Nov 6 104(45):17783-8. Epub 2007 Oct 26

Adam O, Frost G, Custodis F, Sussman MA, Schäfers HJ, Böhm M, Laufs U Role of Rac1 GTPase activation in atrial fibrillation. J Am Coll Cardiol 2007 Jul 24 50(4):359-67. Epub 2007 Jul 06

Gude N, Muraski J, Rubio M, Kajstura J, Schaefer E, Anversa P, Sussman MA Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res 2006 Aug 18 99(4):381-8. Epub 2006 Jul 13

Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A 2006 Aug 8 103(32):11946-51. Epub 2006 Aug 01

Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, Glembotski CC Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ Res 2006 Aug 4 99(3):275-82. Epub 2006 Jun 22

Martindale JJ, Fernandez R, Thuerauf D, Whittaker R, Gude N, Sussman MA, Glembotski CC Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ Res 2006 May 12 98(9):1186-93. Epub 2006 Apr 06

Sussman MA Cause of death: a “broken” MEKK? J Mol Cell Cardiol 2006 May 40(5):593-6. Epub 2006 Apr 04

Brown JH, Del Re DP, Sussman MA The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ Res 2006 Mar 31 98(6):730-42.

Rota M, Boni A, Urbanek K, Padin-Iruegas ME, Kajstura TJ, Fiore G, Kubo H, Sonnenblick EH, Musso E, Houser SR, Leri A, Sussman MA, Anversa P Nuclear targeting of Akt enhances ventricular function and myocyte contractility. Circ Res 2005 Dec 9 97(12):1332-41. Epub 2005 Nov 17

Buscemi N, Murray C, Doherty-Kirby A, Lajoie G, Sussman MA, Van Eyk JE Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy. Am J Physiol Heart Circ Physiol 2005 Dec 289(6):H2325-33. Epub 2005 Sep 09

Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest 2005 Oct 115(10):2716-30.

Plank DM, Sussman MA Impaired intracellular Ca2+ dynamics in live cardiomyocytes revealed by rapid line scan confocal microscopy. Microsc Microanal 2005 Jun 11(3):235-43.

Steinberg SF, Sussman MA Cardiac hypertrophy served with protein kinase Cepsilon: delta isoform substitution available at additional cost. Circ Res 2005 Apr 15 96(7):711-3.

Tsujita Y, Kato T, Sussman MA Evaluation of left ventricular function in cardiomyopathic mice by tissue Doppler and color M-mode Doppler echocardiography. Echocardiography 2005 Mar 22(3):245-53.

Melendez J, Turner C, Avraham H, Steinberg SF, Schaefer E, Sussman MA Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem 2004 Dec 17 279(51):53516-23. Epub 2004 Aug 22

Anversa P, Sussman MA, Bolli R Molecular genetic advances in cardiovascular medicine: focus on the myocyte. Circulation 2004 Jun 15 109(23):2832-8.

Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res 2004 Apr 16 94(7):884-91. Epub 2004 Feb 26

Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res 2004 Mar 5 94(4):514-24. Epub 2004 Jan 15

Sussman MA, Anversa P Myocardial aging and senescence: where have the stem cells gone? Annu Rev Physiol 2004 66:29-48.

Buscemi N, Doherty-Kirby A, Sussman MA, Lajoie G, Van Eyk JE Proteomic analysis of Rac1 transgenic mice displaying dilated cardiomyopathy reveals an increase in creatine kinase M-chain protein abundance. Mol Cell Biochem 2003 Sep 251(1-2):145-51.

Sussman MA ICER-capades: putting cardiac cyclic AMP signaling “on ice”. Circ Res 2003 Jul 11 93(1):6-8.

Plank DM, Yatani A, Ritsu H, Witt S, Glascock B, Lalli MJ, Periasamy M, Fiset C, Benkusky N, Valdivia HH, Sussman MA Calcium dynamics in the failing heart: restoration by beta-adrenergic receptor blockade. Am J Physiol Heart Circ Physiol 2003 Jul 285(1):H305-15. Epub 2003 Mar 20

Sayen MR, Gustafsson AB, Sussman MA, Molkentin JD, Gottlieb RA Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. Am J Physiol Cell Physiol 2003 Feb 284(2):C562-70. Epub 2002 Oct 23

Plank DM, Sussman MA Intracellular Ca2+ measurements in live cells by rapid line scan confocal microscopy: simplified calibration methodology. Methods Cell Sci 2003 25(3-4):123-33.

Melendez J, Welch S, Schaefer E, Moravec CS, Avraham S, Avraham H, Sussman MA Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. J Biol Chem 2002 Nov 22 277(47):45203-10. Epub 2002 Sep 12

Sussman MA, McCulloch A, Borg TK Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy. Circ Res 2002 Nov 15 91(10):888-98.

Welch S, Plank D, Witt S, Glascock B, Schaefer E, Chimenti S, Andreoli AM, Limana F, Leri A, Kajstura J, Anversa P, Sussman MA Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Circ Res 2002 Apr 5 90(6):641-8.

Sussman MA Cellular indigestion: chaperones head to the cytoskeleton. J Mol Cell Cardiol 2002 Feb 34(2):83-5.

Sussman MA When the thyroid speaks, the heart listens. Circ Res 2001 Sep 28 89(7):557-9.

Camper-Kirby D, Welch S, Walker A, Shiraishi I, Setchell KD, Schaefer E, Kajstura J, Anversa P, Sussman MA Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res 2001 May 25 88(10):1020-7.

Yang J, Moravec CS, Sussman MA, DiPaola NR, Fu D, Hawthorn L, Mitchell CA, Young JB, Francis GS, McCarthy PM, Bond M Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays. Circulation 2000 Dec 19 102(25):3046-52.

Delling U, Sussman MA, Molkentin JD Re-evaluating sarcoplasmic reticulum function in heart failure. Nat Med 2000 Sep 6(9):942-3.

Babu GJ, Lalli MJ, Sussman MA, Sadoshima J, Periasamy M Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol 2000 Aug 32(8):1447-57.

Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Witt SA, Kimball TR, Price R, Lim HW, Molkentin JD Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice. Cardiovasc Res 2000 Apr 46(1):90-101.

Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Price RL, Schaefer E, Yager K Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. J Clin Invest 2000 Apr 105(7):875-86.

Lim HW, De Windt LJ, Mante J, Kimball TR, Witt SA, Sussman MA, Molkentin JD Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition. J Mol Cell Cardiol 2000 Apr 32(4):697-709.

Sussman MA, Welch S, Gude N, Khoury PR, Daniels SR, Kirkpatrick D, Walsh RA, Price RL, Lim HW, Molkentin JD Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice. Am J Pathol 1999 Dec 155(6):2101-13.

Sussman MA, Lim HW, Gude N, Taigen T, Olson EN, Robbins J, Colbert MC, Gualberto A, Wieczorek DF, Molkentin JD Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science 1998 Sep 11 281(5383):1690-3.

Sussman MA, Baqué S, Uhm CS, Daniels MP, Price RL, Simpson D, Terracio L, Kedes L Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils. Circ Res 82(1):94-105.

Sussman MA, Welch S, Cambon N, Klevitsky R, Hewett TE, Price R, Witt SA, Kimball TR Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice. J Clin Invest 1998 Jan 1 101(1):51-61.

Sussman MA, Hamm-Alvarez SF, Vilalta PM, Welch S, Kedes L Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis. Circ Res 1997 Jan 80(1):52-61.

Sussman MA, Ito M, Daniels MP, Flucher B, Buranen S, Kedes L Chicken skeletal muscle tropomodulin: novel localization and characterization. Cell Tissue Res 1996 Aug 285(2):287-96.

Sussman MA, McAvoy JW, Rudisill M, Swanson B, Lyons GE, Kedes L, Blanks J Lens tropomodulin: developmental expression during differentiation. Exp Eye Res 1996 Aug 63(2):223-32.

Przyklenk K, Sussman MA, Simkhovich BZ, Kloner RA Does ischemic preconditioning trigger translocation of protein kinase C in the canine model? Circulation 1995 Sep 15 92(6):1546-57.

Ito M, Swanson B, Sussman MA, Kedes L, Lyons G Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis. Dev Biol 1995 Jan 167(1):317-28.

Sussman MA, Sakhi S, Barrientos P, Ito M, Kedes L Tropomodulin in rat cardiac muscle. Localization of protein is independent of messenger RNA distribution during myofibrillar development. Circ Res 1994 Aug 75(2):221-32.

Sussman MA, Sakhi S, Tocco G, Najm I, Baudry M, Kedes L, Schreiber SS Neural tropomodulin: developmental expression and effect of seizure activity. Brain Res Dev Brain Res 1994 Jul 15 80(1-2):45-53.

Sussman MA, Bilak M, Kedes L, Engel WK, Askanas V Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions. Exp Cell Res 1993 Dec 209(2):388-91.

Sussman MA, Fowler VM Tropomodulin binding to tropomyosins. Isoform-specific differences in affinity and stoichiometry. Eur J Biochem 1992 Apr 1 205(1):355-62.

Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. J Biol Chem 1992 Feb 5 267(4):2616-21.

Shubin RA, Sussman MA, Fleming JO, Stohlman SA Relapsing encephalomyelitis following transfer of partial immunity to JHM virus. Microb Pathog 1990 May 8(5):305-14.

Sussman MA, Battenberg E, Bloom FE, Fowler VM Identification of two nerve growth factor-induced polypeptides in PC12 cells. J Mol Neurosci 1990 2(3):163-74.

Sussman MA, Shubin RA, Kyuwa S, Stohlman SA T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system. J Virol 1989 Jul 63(7):3051-6.

Fleming JO, Shubin RA, Sussman MA, Casteel N, Stohlman SA Monoclonal antibodies to the matrix (E1) glycoprotein of mouse hepatitis virus protect mice from encephalitis. Virology 1989 Jan 168(1):162-7.

Stohlman SA, Sussman MA, Matsushima GK, Shubin RA, Erlich SS Delayed-type hypersensitivity response in the central nervous system during JHM virus infection requires viral specificity for protection. J Neuroimmunol 1988 Sep 19(3):255-68.

Sussman MA, Fleming JO, Allen H, Stohlman SA Immune mediated clearance of JHM virus from the central nervous system. Adv Exp Med Biol 1987 218:399-410.

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